Links: (8)
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- UPLIFT Study - A 4-Year Trial of Tiotropium in Chronic Obstructive Pulmonary Disease
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In patients with COPD, therapy with tiotropium was associated with improvements in lung function, quality of life, and exacerbations during a 4-year period but did not significantly reduce the rate of decline in FEV1
- TORCH Survival Study Protocol
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The "Towards a Revolution in COPD Health" survival study is the largest ever, multicentre, long-term COPD study, and the first to investigate the effect of salmeterol/fluticasone proropionate combination and its components on COPD mortality.
- TORCH - Salmeterol and Fluticasone Propionate and Survival
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During the 3 years of the study, treatment with the combination regimen resulted in significantly fewer exacerbations and improved health status and lung function, as compared with placebo.
- The Human and Economic Burden of COPD: A Leading Cause of Hospital Admission in Canada
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The report examines recent Canadian COPD data and reveals that COPD exacerbations result in more hospitalizations than other major chronic diseases, including heart failure, angina and diabetes. These hospitalizations place a great burden on patients, reducing their quality of life, and place strain on the Canadian healthcare system.
- Effect of tiotropium on outcomes in patients with moderate chronic obstructive pulmonary disease (UPLIFT): a prespecified subgroup analysis of a randomised controlled trial
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Tiotropium seemed to reduce the rate of decline of postbronchodilator FEV1 in patients with GOLD stage II COPD. This finding and the other improvements in outcomes suggest that treatment of COPD should begin at an early stage of the disease.
- Economic Benefits of Self-Management Education in COPD
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The program of self-management in COPD holds promise for positive economic benefits with increased patient caseload and rising costs of hospitalization.
- CLIMB - Efficacy and Tolerability of Budesonide/Formoterol Added to Tiotropium in Patients with Chronic Obstructive Pulmonary Disease
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In patients with chronic obstructive pulmonary disease, budesonide/formoterol added to tiotropium versus tiotropium alone provides rapid and sustained improvements in lung function, health status, morning symptoms and activities, and reduces severe exacerbations.
- BOLD STUDY - International variation in the prevalence of COPD: a population-based prevalence study
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This worldwide study showed higher levels and more advanced staging of spirometrically confirmed COPD than have typically been reported.
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